Prof. Ahmed Yaqinuddin

Focus of research

Dr. Ahmed Yaqinuddin is a distinguished researcher in the field of epigenetics, with a particular emphasis on the epigenetic mechanisms that underlie a variety of chronic diseases and malignancies, such as genitourinary, liver, and gastrointestinal (GI) cancers. His extensive research focuses on the complex mechanisms by which epigenetic modifications, including DNA methylation and microRNA expression, contribute to the development and progression of these malignancies. Dr. Yaqinuddin's research endeavors to establish a connection between laboratory discoveries and clinical applications. He is profoundly committed to the advancement of point-of-care diagnostic tests that can aid in the early detection of cancer. Dr. Yaqinuddin's innovative approaches have the potential to revolutionize cancer screening and management by providing minimally invasive, efficient, and accurate diagnostic tools that are based on cell-free microRNAs and DNA methylation markers found in body fluids.

Dr. Yaqinuddin has made significant contributions to the comprehension of the inflammatory processes that are involved in a variety of diseases in addition to his cancer research. His research has illuminated the role of Neutrophil Extracellular Traps (NETs) in the pathophysiology of COVID-19, demonstrating how NETs contribute to severe disease manifestations and complications. He has broadened this investigation to encompass chronic conditions, including Alzheimer's disease, diabetes, and a variety of malignancies, thereby clarifying the intricate relationship between inflammation, immunity, and the development of chronic diseases.

Dr. Yaqinuddin's interdisciplinary approach integrates clinical research, epigenetics, and molecular biology to confront some of the most urgent issues in contemporary medicine. His pioneering research has paved the way for significant progress in the early diagnosis and treatment of cancer, as well as a comprehensive understanding of chronic diseases related to inflammation.

Five recent publications

1. Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma. L Ramachandran, F Abul Rub, A Hajja, I Alodhaibi, M Arai, M Alfuwais, ...Biosensors 14 (5), 235 2024
2. Urinary biomarkers for lupus nephritis: a systems biology approach. MH Omer, A Shafqat, O Ahmad, J Nadri, K AlKattan, A Yaqinuddin. Journal of Clinical Medicine 13 (8), 2339, 2024.
3. Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges. A Jabri, J Khan, B Taftafa, M Alsharif, A Mhannayeh, R Chinnappan, ...Bioengineering 11 (4), 346 1, 2024.
4. Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives. A Noor Eddin, M Alfuwais, R Noor Eddin, K Alkattan, A Yaqinuddin. Nutrients 16 (5), 590, 2024.
5. Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications. C Jazieh, TZ Arabi, Z Asim, BN Sabbah, AW Alsaud, K Alkattan, ...Frontiers in Endocrinology 15, 1295967 1, 2024.
6. Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease. S Adeeb, TZ Arabi, H Shah, S Alsalameh, M Abu-Shaar, AM El-Sibai, ...Journal of Clinical Medicine 13 (2), 512

Abdul Khalid Siraj, Ph.D.

Focus of research

His research interests include translational research, molecular characterization of cancers and therapeutic targets. He recently focused on high throughput sequencing techniques for analyzing mutations in different cancers such as thyroid, colorectal, and breast. Targeting these identified molecular and genetic alterations using either molecular inhibitors, small interference RNA (siRNA) or antibodies are also performed to identify genes that can be therapeutically targeted for the improvement of cancer therapy.

Five recent publications

1. Radioactive iodine refractoriness in Middle Eastern differentiated thyroid cancer: clinical outcome and risk factor analysis. Frontiers in Endocrinology. 2024 May 15, DOI:10.3389/fendo.2024.1326976
2. Predicting factors and clinical outcome of biochemical incomplete response in middle eastern differentiated thyroid carcinoma. Endocrine. 2024 May 2. doi: 10.1007/s12020-024-03844-x. PMID: 38696058
3. Recurrent Middle Eastern Differentiated Thyroid Carcinoma Has Worse Outcomes Than Persistent Disease. J Clin Med. 2024 Mar 25;13(7):1877. doi: 10.3390/jcm13071877. PMID: 38610642
4. PLK1 and PARP positively correlate in Middle Eastern breast cancer and their combined inhibition overcomes PARP inhibitor resistance in triple negative breast cancer. Front Oncol. 2024 Jan 3;13:1286585. doi: 10.3389/fonc.2023.1286585. eCollection 2023.PMID: 38234395
5. PLK1 and PARP positively correlate in Middle Eastern breast cancer and their combined inhibition overcomes PARP inhibitor resistance in triple negative breast cancer. Front Oncol. 2024 Jan 3;13:1286585. doi: 10.3389/fonc.2023.1286585. eCollection 2023.PMID: 38234395.
6. PLK1 and FoxM1 positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti-tumor effects. Mol Oncol. 2024 Feb 15. doi: 10.1002/1878-0261.13610. Online ahead of print.PMID: 38361222

Abdelilah Aboussekhra, Ph.D.

Focus of research

The role of cancer-associated fibroblasts in breast carcinogenesis and the role of secreted cytokines in this crosstalk between cancer cells and their protective fibroblasts. We are aslo interested in developing drugs to target both cancer cells and also their associated fibroblasts. These drugs are also tested against other types of cancer such as ovarian, colerectal, and bone.

Five recent publications

1. Syed S Islam, Falah H Al-Mohanna , Iman M Yousef , Ismail A Al-Badawi , Abdelilah Aboussekhra. Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells. Cell Death Dis. 2024 Apr 4;15(4):247. doi: 10.1038/s41419-024-06512-0.
2. Islam SS, Al-Tweigeri T, Al-Harbi L, Ujjahan S, Al-Mozaini M, TulbahA, Aboussekhra A. Long noncoding RNA DLEU2 and ROR1 pathway induces epithelial-to-mesenchymal transition and cancer stem cells in breast cancer. Cell Death Discov. 2024 Jan 31;10(1):61. doi: 10.1038/s41420-024-01829-3
3. Wafaa A Aljagthmi, Manal A Alasmari, Maha H Daghestani, Layla A Al-Kharashi, Falah H Al-Mohanna, Abdelilah Aboussekhra. Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling. Cells, 2024 Apr 14;13(8):680. doi: 10.3390/cells13080680
4. Abdelilah Aboussekhra, Noura N. Alraouji, Falah Al-Mohanna, Huda Al-Khalaf. Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects. Transl Oncol. 2023 Nov:37:101780. doi: 10.1016/j.tranon.2023.101780
5. Aboussekhra A, Islam SS, Alraouji NN. Activated breast stromal fibroblasts exhibit myoepithelial and mammary stem cells features. Transl Oncol. 2023. Sep:35:101721. doi: 10.1016/j.tranon.2023.101721.

Islam Mohamed Saadeldin Mohamed

Scopus Name: Islam M. Saadeldin
Email: imohamed@kfshrc.edu.sa

Focus of research

Dr. Saadeldin's research extends across various facets of reproductive biotechnology, including somatic cell nuclear transfer (SCNT), transgenesis, endometrial organoids, adult, and embryonic stem cells. Dr. Saadeldin's scholarly pursuits delve into the intricate roles played by extracellular vesicles or exosomes in embryo communication and modeling the dynamic interactions between embryonic and maternal compartments.

One of his notable research directions involves studying comparative cellular defense mechanisms against extreme hyperthermia, exploring correlations with cellular anastasis and resilience. Currently, his research trajectory is centered around the development of CRISPR/Cas9-engineered extracellular vesicles, with the overarching goal of enhancing embryo implantation and improving pregnancy outcomes. Additionally, he is leading a project regarding the oncofertility and how to preserve the female fertility from the chemotherapy through the use of stem cells-derived exosomes.

Five recent publications

1. Abady M, Jeong J, Kwon H, Assiri A, Cho J, Saadeldin IM.* (2024) The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models. Front. Pharmacol. 15 https://doi.org/10.3389/fphar.2024.1412188.
2. . Saadeldin IM, Ehab S, Noreldin AE, Swelum AA, Bang S, Kim H, Yoon K, Lee S, Cho J. (2024) The current strategies using 3D organoids to establish in-vitro maternal-embryonic interaction. Journal of Veterinary Science 25(3):e40 https://doi.org/10.4142/jvs.24004.
3. Saadeldin, I.M., Han, A., Bang, S., Kang, H., Kim, H., Abady, M. M., Jeong, J., Kwon, H., Lee, S., & Cho, J. (2024). Generation of porcine endometrial organoids and their use as a model for enhancing embryonic attachment and elongation. Reproduction 167(2): e230429. https://doi.org/10.1530/REP-23-0429.
4. Saadeldin IM*, Ehab S, Cho J. (2023) Significance of multilamellar and multicompartmental vesicles in biological fluids: understanding the significance of proportional variations and disease correlation. Biomarker Research, 11: 77. https://doi.org/10.1186/s40364-023-00518-0
5. Saadeldin IM, Bang S, Maigoro A, Kim S, Sung L, Lee S, Cho J. (2023) Proteomic analysis and reprogramming potential of the porcine intra-ooplasmic nanovesicles. Cellular Reprogramming, 25(5): 238–250. https://doi.org/10.1089/cell.2023.0050.

Fatimah Saeed Alhamlan, PhD

Focus of research

Currently, Dr. Alhamlan’s lab is spearheading the Microbial Genomic and Epidemiological Surveillance System at KFSH&RC. Research focuses mainly on emerging and re-emerging pathogens, sexually transmitted infections (STIs), HPV-related cancers, and microbiomes. Additionally, we are actively engaged in developing in-house diagnostic tests, including localized encephalitis and CMV drug-resistance tests, to ensure prompt and accurate diagnoses for ultimate patient care.

Five recent publications

1. Characteristics and Clinical Manifestations of Patients, Including Organ Transplant Patients, during the Surge of JN. 1: Insights from Saudi Arabia. Obeid D, Al-Qahtani A, Almaghrabi R, Alahideb B, Alharbi L., Al-Abdulkareem M, Almadi T., Alsanae M., Altamimi S, Althawadi S, Alhamlan F. J Infect Public Health. (2024). doi.org/10.1016/j.jiph.2024.05.040
2. Low uptake of Pap test as a cervical cancer screen among Saudi women: Findings from a national survey. Alfareh M, Obeid D, Alhoshan H, Basri R, Alhamlan F. Int J Gynaecol Obstet. (2024). PMID: 38641900
3. Genomic Surveillance and Mutation Analysis of SARS-CoV-2 Variants among Patients in Saudi Arabia. Alsuwairi F, Alsaleh M, Obeid D, Al-Qahtani A, Almaghrabi R, Alahideb B, AlAbdulkareem M, Alsanea M, Alharbi L, Althawadi S, Altamimi S, Alshukairi A, Alhamlan F. Microorganisms (2024). PMID: 38543518.
4. Analysis of SARS-CoV-2 genomic surveillance data during the Delta and Omicron waves at a Saudi tertiary referral hospital. Obeid D, Al-Qahtani A, Almaghrabi R, Alghamdi S, Alsanea M, Alahideb B, Almutairi S, Alsuwairi F, Al-Abdulkareem M, Asiri M, Alshukairi A, Alkahtany J, Altamimi S, Mutabagani M, Althawadi S, Alanzi F, Alhamlan F. J Infect Public Health. (2023). PMID: 36543031
5. Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women. Alsanea, M., Alsaleh, A., Obeid, D., Alhadeq, F., Alahideb, B., Alhamlan, F. Viruses (2023). 15(1), 109. ORCID ID: 0000-0003-1765-4310

Monther Al-Alwan, MSc, PhD

Focus of research

Breast cancer is the most common cancer in women worldwide. Despite progress in drug development against specific target in breast cancer, tumor related mortality remain high due disease relapse. Fascin is an actin-bundling protein that get expressed in many type of cancers including breast. Impotently, our lab demonstrated that fascin expression levels is linked to many poor prognostic markers including drug resistance and metastasis, major contributors in disease relapse and shorter survival. Breast cancer are classified into 4 major molecular subtypes. Luminal A), luminal B, HER2-enriched and triple negative breast cancer (TNBC). Subtyping of breast cancer is required for defining the appropriate treatment and distinguishing the good responders from high risk subtype. Fascin is expressed in 15-25% of luminal A and B, which account for around 70% of all cases and are the least aggressive of the 4 breast cancer subtypes. HER2-encirhced (40-50% are fascin positive) accounts for 20-30% of diagnosed breast cancers and more aggressive than luminal, but is less aggressive than TNBC (85% are fascin positive) which makes up between 15-20% of the cases. Luminal A and B breast cancer have better prognosis due to the high sensitivity to anti-estrogen hormonal therapy, while HER2-enirched breast cancer can be treated with anti-HER2 antibodies, adjuvant and/or chemotherapy. However, TNBC are the most aggressive and had the least therapeutic options. However, disease relapse remain high among breast cancer patients, thus necessitating the need for an alternative therapy. Since we established a direct link between fascin expression and poor prognosis, our lab is focused on manipulating fascin expression in different breast cancer cell line model. This help us to combines in vitro assay, preclinical studies in animal and patient sample as a first step toward understanding fascin’s function in the progression of breast cancer. Ongoing clinical trials using small molecule targeting fascin in solo or in combination with other therapies showed promising results for multiple type of malignancies. Deep understating of fascin’s function in breast cancer cells may help in designing the best combinational therapy especially for drug resistant and metastatic breast cancer.

Five recent publications

1. Fascin is essential for mammary gland lactogenesis. Al-Khaldi S, Almohanna F, Barnawi R, Fallatah M, Islam SS, Ghebeh H, Al-Alwan M.Dev Biol. 2022 Dec;492:25-36. doi: 10.1016/j.ydbio.2022.09.003. Epub 2022 Sep 21.PMID: 36152869 Free article.
2. Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression. Barnawi R, Al-Khaldi S, Majid S, Qattan A, Bakheet T, Fallatah M, Ghebeh H, Alajez NM, Al-Alwan M.Pharmaceuticals (Basel). 2021 Nov 26;14(12):1228. doi: 10.3390/ph14121228.PMID: 34959629 Free PMC article.
3. Fascin Activates β-Catenin Signaling and Promotes Breast Cancer Stem Cell Function Mainly Through Focal Adhesion Kinase (FAK): Relation With Disease Progression. Barnawi R, Al-Khaldi S, Bakheet T, Fallatah M, Alaiya A, Ghebeh H, Al-Alwan M.Front Oncol. 2020 Apr 21;10:440. doi: 10.3389/fonc.2020.00440. eCollection 2020.PMID: 32373510 Free PMC article.
4. β1 Integrin is essential for fascin-mediated breast cancer stem cell function and disease progression. Barnawi R, Al-Khaldi S, Colak D, Tulbah A, Al-Tweigeri T, Fallatah M, Monies D, Ghebeh H, Al-Alwan M.Int J Cancer. 2019 Aug 1;145(3):830-841. doi: 10.1002/ijc.32183. Epub 2019 Feb 18.PMID: 30719702 Free PMC article.
5. Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway. Barnawi R, Al-Khaldi S, Majed Sleiman G, Sarkar A, Al-Dhfyan A, Al-Mohanna F, Ghebeh H, Al-Alwan M.Stem Cells. 2016 Dec;34(12):2799-2813. doi: 10.1002/stem.2473. Epub 2016 Aug 21.PMID: 27502039

Edreese Alsharaeh PhD

Focus of research

Nanostructure Materials for Biomedical application including theragnostic platforms, drug delivery systems, biomaterial/device coatings, tissue engineering scaffolds, performance-enhanced therapeutic alternatives.

Five recent publications

1. Navigating the hydrogen prospect: A comprehensive review of sustainable source-based production technologies, transport solutions, advanced storage mechanisms, and CCUS integration. S Tasleem, CS Bongu, MR Krishnan, EH Alsharaeh. Journal of Energy Chemistry 2024
2. Coated nanosand as relative permeability modifier. A Almohsin, E Alsharaeh, MR Krishnan, M Alghazali. US Patent 11,993,750, 2024.
3. Improving Water Retention in Sandy Soils with High-Performance Superabsorbents Hydrogel Polymer. H Omar, E Alsharaeh. ACS Omega 2024
4. Mechanical strength investigation of chemically reinforced sandy soil using organic copolymers for geotechnical engineering applications. MR Krishnan, EH Alsharaeh. Journal of Polymer Science and Engineering 7 (1), 5170, 2024.
5. Facile fabrication of thermo-mechanically reinforced polystyrene-graphene nanocomposite aerogel for produced water treatment. MR Krishnan, EH Alsharaeh. Journal of Porous Materials, 1-11 1, 2024.

Prof. Namik Kaya

Prof. Namik Kaya (earned his PhD in 1997, The Ohio State University, Columbus, OH, USA). Currently, he is a senior scientist and head of Neurogenetics Unit in Translational Genomics department at the Center for Genomic Medicine, KFSHRC. He received his professorship in human genetics/genomics in 2018.

Focus of research

Dr. Namik Kaya has received his PhD from the Ohio State University in 1997. He did his postdoctoral studies at the same university. He joined King Faisal Specialist Hospital and Research Centre (KFSHRC) in 2004. He then established Neurogenetics Unit within the Department of Genetics. Dr. Kaya’s research interests include genetics of neurological disorders, particularly ataxias, leukodystrophies, and channelopathies, genetics of neurodevelopmental disorders, mitochondrial disorders, and integrated omics for precision medicine. He has a strong track record of scientific publication and securing grant funds. Currently he is principal investigator of several critical projects (including an international clinical trial) several of which are funded by different funding agencies. He has over 100 scientific publications in various peer-reviewed international journals. His lab discovered several disease-causing novel genes and novel syndromes such as KAYA-BARAKAT-MASSON Syndrome, OMIM# 619125; and BARAKAT-VAN HAM-KAYA Syndrome, OMIM# 619389. Dr. Kaya holds Professorship in Human Genetics and Genomics and was the recipient of KFSHRC’s prestigious “The Best Publication Award” for six consecutive years. He has been widely recognized for his training and educational activities and received numerous recognition awards for his efforts. Dr. Kaya has been serving on the editorial board (Genetics Section) of PLoS ONE, and reviews grants for funding agencies such as King Abdulaziz City of Science and Technology and King Salman Center for Disability Research. He is member of American Society of Human Genetics (ASHG), European Society of Human Genetics, and Society for Neuroscience. Currently, he is leading Neurogenetics Unit in Translational Genomics Department at the Center for Genomic Medicine, KFSHRC.

Five recent publications

1. Lace B, Faqeih E, Kaya N, Krumina Z, Mayr JA, Micule I, Wright NT, Achleitner MT, AlQudairy H, Pajusalu, Stavusis J, Zayakin P, Inashkina I. The phenotypic spectrum of PTCD3 deficiency. JIMD Reports. 2024;1–8. Accepted: 18 April 2024, DOI: 10.1002/jmd2.12424
2. Deng R, Medico-Salsench E, Nikoncuk A, Ramakrishnan R, Lanko K, Kühn NA, van der Linde HC, Lor-Zade S, Albuainain F, Shi Y, Yousefi S, Capo I, van den Herik EM, van Slegtenhorst M, van Minkelen R, Geeven G, Mulder MT, Ruijter GJG, Lütjohann D, Jacobs EH, Houlden H, Pagnamenta AT, Metcalfe K, Jackson A, Banka S, De Simone L, Schwaede A, Kuntz N, Palculict TB, Abbas S, Umair M, AlMuhaizea M, Colak D, AlQudairy H, Alsagob M, Pereira C, Trunzo R, Karageorgou V, Bertoli-Avella AM, Bauer P, Bouman A, Hoefsloot LH, van Ham TJ, Issa M, Zaki MS, Gleeson JG, Willemsen R, Kaya N, Arold ST, Maroofian R, Sanderson LE, Barakat TS. AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathol. 2023 Apr 29. doi: 10.1007/s00401-023-02579-9. Online ahead of print.PMID: 37119330.
3. Altassan R, AlQudairy H, AlJebreen S, AlMuhaizea M, Al-Hindi H, Ghebeh H, Almzroua A, Colak D, AlDosary M, Kaya N*. Expanding the phenotypic and genotypic spectrum of GGPS1 related congenital muscular dystrophy. Am J Med Genet A. 2023 Dec 21. doi: 10.1002/ajmg.a.63498. Epub 2023 Dec 21. PMID: 38129970.
4. AlShail E, Alsagob M, Alahmari AN, Al-Hindi H, Khalil H, Dababo AAM, Al Masseri Z, AlSalamah R, Almohseny E, Alduhaish A, Colak D*, Kaya N*. A molecular study of pediatric pilomyxoid and pilocytic astrocytomas: Genome-wide copy number screening, retrospective analysis of clinicopathological features and long-term clinical outcome (Front Oncol. 2023 Feb 13;13:1034292. DOI:10.3389/fonc.2023.1034292)
5. AlDhalaan H, AlQudairy H, AlRuways S, AlMutairi N, AlNakiyah M, AlGhofaili R, AlBakheet A, AlSayed MD, AlZaidan H, Alrasheed MM, Colak D, Kaya N*. Clinical, radiological, and genetic characterization of SLC13A5 variants in Saudi families: Genotype phenotype correlation and brief review of the literature (Frontiers in Pediatrics, 2023, Feb 27;10:1051534. doi: 10.3389/fped.2022.1051534).

George Kulik, D.V.M., Ph.D.

Associate professor of Cancer Biology

Focus of research

My laboratory investigates signaling pathways that control apoptosis in cancer cells. We identified PI3K/Akt as dominant anti-apoptotic pathway activated by IGF-1 in fibroblasts and by EGF in epithelial cells. Subsequently, we have described a network of signaling pathways that regulate survival of prostate cancer cells and identified BAD (a BH3-only member of Bcl2 family) as a downstream convergence node of multiple anti-apoptotic signaling pathways ( PI3K/Akt, EGFR and GPCRs). We were first to show that stress hormone epinephrine protects prostate cancer cells from apoptosis via PKA/BAD signaling and demonstrated that Epi/ ADRB2/PKA/BAD accelerates progression of prostate tumors in mice.

I have directed multi-investigator research project that demonstrated the role of ADRB2 signaling in prostate cancer and collaborative projects on the development of prostate-selective PI3K inhibitors and prostate-targeted toxins.

Currently my interests shifted to the analysis of signaling pathways that operate in normal prostate and large intestine and in malignancies of these tissues.

Five recent publications

1. Alaskar A, Abdulraqeb Ali A, Hassan S, Shinwari Z, Alaiya A, von Holzen U, Miller L, Kulik G. Inhibition of signaling downstream of beta-2 adrenoceptor by propranolol in prostate cancer cells. Prostate. 2023 Feb;83(3):237-245. doi: 10.1002/pros.24455. Epub 2022 Nov 14. PMID: 36373761; PMCID: PMC10100053.
2. Ali A, Kulik G. Signaling Pathways That Control Apoptosis in Prostate Cancer. Cancers (Basel). 2021 Feb 24;13(5):937. doi: 10.3390/cancers13050937. PMID: 33668112; PMCID: PMC7956765.
3. Hassan S, Pullikuth A, Nelson KC, Flores A, Karpova Y, Baiz D, Zhu S, Sui G, Huang Y, Choi YA, D'Agostino R Jr, Hemal A, von Holzen U, Debinski W, Kulik G. β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1. Mol Cancer Res. 2020 Dec;18(12):1839-1848. doi: 10.1158/1541-7786.MCR-19-1037. Epub 2020 Sep 14. PMID: 32928910; PMCID: PMC8080265.
4. Kulik G. ADRB2-Targeting Therapies for Prostate Cancer. Cancers (Basel). 2019 Mar 13;11(3):358. doi: 10.3390/cancers11030358. PMID: 30871232; PMCID: PMC6468358.
5. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013 Feb;123(2):874-86. doi: 10.1172/JCI63324. Epub 2013 Jan 25. PMID: 23348742; PMCID: PMC3561807.

Peter Cahusac, BSc Hons, PhD, MSc, CStat

Focus of research

Evidence-based medicine and evidence-based statistics. The practical application of evidential statistics (likelihood approach) to the analysis of healthcare data. The in vitro neuropharmacological study of Merkel cell mechanoreceptors.

Five recent publications

1. Aljadaan, M., Alhakbani, M. S., Cahusac, P. M. B., and Monaie, S. H. (2024) Outcomes of Surgical Interventions for Patellofemoral Instability in the Presence of Trochlear Dysplasia: A Systematic Review and Meta-analysis, The American Journal of Sports Medicine, In Press
2. Cahusac, P.M.B. (2024) Likelihood Ratio Test and the Evidential Approach for 2 × 2 Tables, Entropy, 26(5):375 (15) https://doi.org/10.3390/e26050375
3. Abdulrazaq Al-Jazairi, Nahlah Bahammam, Dhai Aljuaid, Lama Almutairi, Shroog Alshahrani, Nourah Albuhairan, Peter Cahusac, Ghazwa Korayem (2023) Cardiovascular Adverse Events of Antineoplastic Monoclonal Antibodies among Cancer Patients: Real-world Evidence from a Tertiary Healthcare System, Cardio-Oncology, 9:35:1-11 https://doi.org/10.1186/s40959-023-00184-z
4. 4. Cahusac, P. (2023) Log Likelihood Ratios For Common Statistical Tests Using The likelihoodR Package, The R Journal, 14(3):203-212 https://doi.org/10.32614/RJ-2022-051
5. 5. Cahusac, P.M.B. & Veermalla, A. (2022) Effects of camphor and related compounds on slowly adapting mechanoreceptors in the rat sinus hair follicle, IBRO Neuroscience Reports, 13:114-119 https://doi.org/10.1016/j.ibneur.2022.07.002

Rajaa M. Adnan Fakhoury

Professor in Medical Biochemistry

Focus of research

My research focuses on two key areas within the fields of molecular medicine and pharmacogenomics:

1. Understanding the Molecular Basis of Chronic Diseases:
• My research aims to elucidate the molecular mechanisms underlying chronic diseases such as diabetes, cancer, hypercholesterolemia, and chronic obstructive pulmonary disease (COPD).
• This knowledge is being leveraged to develop new diagnostic tools and targeted treatments for these complex, multifactorial diseases.
2. Identifying Genetic Determinants of Drug Response:
• I am working to identify genetic variants that influence an individual's metabolism, the efficacy, and the potential for side effects of various medications.
• This pharmacogenomic research is intended to enable more personalized and effective drug therapies, improving patient outcomes and safety.

Five recent publications

1. Batha L, Aziz MA, Zhra M, Holail J, Al-Qahtani WS, Fakhoury R, Aljada A. Differential Gene Expression Signatures and Cellular Signaling Pathways induced by Lamin A/C Transcript Variants in MCF7 Cell Line. Front Biosci (Landmark Ed). 2023 Jun 12;28(6):113.
2. Hana M A Fakhoury , Said El Shamieh , Amru Rifai , Hani Tamim , Rajaa Fakhoury . Vitamin D related gene polymorphisms and cholesterol levels in a Mediterranean population. J Cardiovasc Dev Dis. 2022 Mar 27;9(4):102.
3. Maya idriss , Maria Younes, Sonia Abou Najem, Mohammad Hassan Hodroj , Rajaa Fakhoury , Sandra Rizk . Gamma-tocotrienol synergistically promotes the anti-proliferative and pro-apoptotic effects of etoposide on breast cancer cell lines. Curr Mol Pharmacol. 2022;15(7):980-986.
4. Said El Shamieh , Ali Salami, Mirna Fawaz, Rania Jounblat, Mirna Waked , Rajaa Fakhoury.rs6837671A>G in FAM13A Is a Trans-Ethnic Genetic Variant Interacting with Vitamin D Levels to Affect Chronic Obstructive Pulmonary Disease. J Pers Med. 2021 Jan 30;11(2):84
5. Naja K, El Shamieh S, Salami A., Fakhoury R. rs622342 in SLC22A1, CYP2C9*2 and CYP2C9*3 and Glycemic Response in Individuals with Type 2 Diabetes Mellitus Receiving

Metformin/Sulfonylurea Combination Therapy 6-Month Follow-Up Study. Journal of Personalized Medicine.2020 (10), 53-61.

Prof. Mohammad Khanfar

Focus of research

Dr. Khanfar’s research involves the use of state-of-the-art pharmaceutical, computational, and medicinal chemistry technologies to design, synthesize, and evaluate new molecules for the treatment of human diseases and to probe biological systems, with a particular emphasis on cancer and neurodegenerative diseases. His research is pioneering in the development of novel computational and molecular modeling technologies aimed at understanding protein-drug interactions and discovering novel, active drugs.

Dr. Khanfar’s research team employs a comprehensive suite of computer-aided drug design methods. These include multidimensional quantitative structure-activity relationship (QSAR) models, which correlate the chemical structure of compounds with their biological activity, docking techniques that predict the preferred orientation of one molecule to a second when bound to each other, conformational analysis to understand the shape and flexibility of molecules, and pharmacophore modeling to identify the structural features responsible for a drug's biological activity. These methods collectively enhance the understanding of drug action and facilitate the design and discovery of new therapeutics.

In addition to computational techniques, Dr. Khanfar applies synthetic and medicinal chemistry methods to design and synthesize new therapeutics, specifically targeting oncology and neurodegenerative diseases. His innovative work in synthetic chemistry has led to the creation of several chemical scaffolds aimed at cancer-related kinases. These kinases play crucial roles in the regulation of cell functions, and their dysregulation is often associated with cancer. Moreover, Dr. Khanfar has developed modulators of Histamine subtype 3 (H3 receptors), which are significant in the context of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. These modulators have the potential to improve cognitive functions and offer new therapeutic avenues for treating these debilitating conditions.

Five recent publications

1. Mohammad A. Khanfar, Nada Salaas (2024): 3-(phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors. Submitted to Bioorganic & Medicinal Chemistry Letters.
2. Mohammad A. Khanfar, Mohammad Saleh (2023): SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for Treatment of Coronaviridae Infections. Phototherapy Research (IF = 7.2) Accepted.
3. Mohammad A. Khanfar, Nada Salass, Reem Abumostafa (2023): Discovery of Natural-Derived Mpro Inhibitors as Therapeutic Candidates for COVID-19: Structure-Based Pharmacophore Screening Combined with QSAR Analysis. Molecular Informatics (IF = 4.05). 42 (4) 2200198.
4. Mohammad A. Khanfar, Ibrahim M Salman, Omar Z Ameer (2022): Synthesis and Biological Evaluation of Thiazole-Based Fibroblast Growth Factor Receptor-1 Inhibitors. Anti-cancer Agents in Medicinal Chemistry (I.F. = 2.50), DOI: 10.2174/1871520622666220905141248
5. Mohammad A. Khanfar (2022): Novel Oxadiazol-Based mTOR inhibitors with Potent Antiproliferative Activities. Synthetic and Computational Modeling. Molecular Diversity (I.F. = 3.36), 26, 3357–3364.

Atef M. Shibl, PhD

Focus of research

• Surveillance of antibiotics resistance and their mechanism of resistance
• Effect of Antibiotics on host parasite relationship
• Effect of vaccination on bacterial resistant to antibiotics
• Pattern of serotypes among bacterial causing meningitis Infection control practice within hospital settings
• Evaluation of antiseptics, disinfectant and sterilization process used in hospitals

Five recent publications

1. Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia.
   Alzayer M, Alkhulaifi MM, Alyami A, Aldosary M, Alageel A, Garaween G, Shibl A, Al-Hamad AM, Doumith M. Front Cell Infect Microbiol. 2024 Apr 22;14:1377993. doi: 10.3389/fcimb.2024.1377993. eCollection 2024. PMID: 38711928
2. Epidemiology of Reportable Bacterial Infectious Diseases in Saudi Arabia.
   Alhumaid NK, Alajmi AM, Alosaimi NF, Alotaibi M, Almangour TA, Nassar MS, Memish ZA, Binjomah AZ, Al-Jedai A, Almutairi AS, Algarni S, Alshiban NM, Aleyiydi MS, Tawfik AF, Shibl A, Tawfik EA. Infect Dis Ther. 2024 Apr;13(4):667-684. doi: 10.1007/s40121-024-00942-1. Epub 2024 Mar 10. PMID: 38461481
3. Molecular typing and antimicrobial resistance of group B Streptococcus clinical isolates in Saudi Arabia.
   Alzayer M, Alkhulaifi MM, Alyami A, Aldosary M, Alageel A, Garaween G, Shibl A, Al-Hamad AM, Doumith M. J Glob Antimicrob Resist. 2023 Dec;35:244-251. doi: 10.1016/j.jgar.2023.10.007. Epub 2023 Oct 14. PMID: 37844802
4. Macrolides for better resolution of community-acquired pneumonia: A global meta-analysis of clinical outcomes with focus on microbial aetiology.
   Kyprianou M, Dakou K, Aktar A, Aouina H, Behbehani N, Dheda K, Juvelekian G, Khattab A, Mahboub B, Nyale G, Oraby S, Sayiner A, Shibl A, El Deen MAT, Unal S, Zubairi ABS, Davidson R, Giamarellos-Bourboulis EJ. Int J Antimicrob Agents. 2023 Oct;62(4):106942. doi: 10.1016/j.ijantimicag.2023.106942. Epub 2023 Aug 3. PMID: 37541531
5. Assessing the knowledge and attitude towards HIV/AIDS among the general population and health care professionals in MENA region.
   Elghazaly A, AlSaeed N, Islam S, Alsharif I, Alharbi L, Al Ashagr T, Alshanifi A, Alrashoudi R, Alsharidi A, Alhokail A, Dirar Q, Shibl A, Al-Kattan K, Abothneen N, Al-Mozaini M. PLoS One. 2023 Jul 27;18(7):e0288838. doi: 10.1371/journal.pone.0288838. eCollection 2023. PMID: 37498957
6. The Risk of Latent Tuberculosis Infection Among Healthcare Workers at a General Hospital in Bisha, the Kingdom of Saudi Arabia.
   Alshahrani NS, Kayal M, Alahmad Almshhad H, Dirar Q, AlKattan W, Shibl A, Ouban A. Cureus. 2023 Jun 17;15(6):e40561. doi: 10.7759/cureus.40561. eCollection 2023 Jun. PMID: 37465781

Khalid Said Mohammad, M.B.B.Ch, MSc, Ph.D

Focus of research

My research primarily focuses on the complex interactions between cancer and bone. Specifically, I am dedicated to investigating how the microenvironment of the bone influences the behavior of tumors and their response to various therapeutic interventions. My focus lies on deciphering the molecular mechanisms that underlie the development of bone metastases and the systemic affects they entail. An integral part of my research is looking into the complex role played by transforming growth factor-beta (TGF-β) in the normal remodeling processes of bone and the progression of metastatic lesions. I am particularly interested in elucidating how TGF-β modulates the activities of osteoblasts and osteoclasts, influencing the advancement of cancer within the bone microenvironment.

Another area of exploration within my research pertains to investigating the contributions of bone-derived TGF-β and other signaling molecules in regulating glucose metabolism. I focus on the involvement of bone marrow adipocytes in the context of bone metastases, offering valuable insights into the metabolic dysfunctions associated with cancer progression.

My research efforts extend to the examination of the influence of endothelin-1 on bone remodeling processes and the formation of osteoblastic metastases. Through a detailed analysis of the signaling pathways activated by endothelin-1 that promote osteoblastic activity and bone formation, I aim to identify new therapeutic targets that could revolutionize the treatment of bone metastases. I am actively involved in studying the impacts of anti-VEGF therapies on both bone metastases and normal bone development, with the goal of refining cancer treatment strategies to minimize adverse effects on bone health.

Another aspect of my research involves the rigorous evaluation of novel anticancer compounds using animal models of bone metastases. This preclinical research phase is indispensable for assessing the efficacy and safety profiles of potential therapeutic agents before they can progress to the clinical trial stage.

Five recent publications

1. Singh P, Mohammad KS, Pelus LM. CXCR4 expression in the bone marrow microenvironment is required for hematopoietic stem and progenitor cell maintenance and early hematopoietic regeneration after myeloablation. Stem Cells. 2020 Mar 11. doi: 10.1002/stem.3174. Online ahead of print.
2. Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells. Liu L, Li H, Patterson AM, Plett PA, Sampson CH, Mohammad KS, Capitano ML, Singh P, Yao C, Orschell CM, Pelus LM. Stem Cell Rev Rep. 2022 Apr;18(4):1478-1494. doi: 10.1007/s12015-022-10368-2. Epub 2022 Mar 23. PMID: 35318613
3. Liu Y, Reiken S, Dridi H, Yuan Q, Mohammad KS, Trivedi T, Miotto MC, Wedderburn-Pugh K, Sittenfeld L, Kerley Y, Meyer JA, Peters JS, Persohn SC, Bedwell AA, Figueiredo LL, Suresh S, She Y, Soni RK, Territo PR, Marks AR, Guise TA. Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice. Sci Transl Med. 2023 Sep 27;15(715):eadf8977. doi: 10.1126/scitranslmed.adf8977. Epub 2023 Sep 27. PMID: 37756377.
4. Elaasser B, Arakil N, Mohammad KS. Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective. Int J Mol Sci. 2024 Feb 29;25(5):2846. doi: 10.3390/ijms25052846. PMID: 38474093
5. Arakil N Elaasser B, Akhund SA, Mohammad KS. Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis Biomedicines 2024, 12(5), 1075https://doi.org/10.3390/biomedicines12051075

Prof. Mohammed Zourob

Focus of research

Prof. Zourob leading the Biosensors BioMEMS and Bionanotechnology Lab (BBBL) at Alfaisal University. The lab has more than 40 active researchers including graduate students, undergraduate students, postdoctoral and visitors from different parts of the world. The lab is a multidisciplinary, where the lab members coming from different backgrounds including science, nanotechnology, biomedical science, pharmacy, medicine, radiology, and engineering. BBBL is extensively engaged with local and international collaborations. More than 120 graduate students and postdoctoral scientists already trained/graduated from the BBBL lab and secured positions in various academic institutions, industry, government jobs, and research entities locally and internationally. The lab is very active in developing rapid diagnostic/detection tools, specific recognition elements, lab on a chip for sample processing and organ on a chip. The lab has active research in developing low-cost paper, colorimetric, electrochemical, optical and soft and flexible materials based-diagnostic tools for various biomedical applications. Another axis of research at BBBL includes the development of various recognition elements such as immunoassays, aptamers, peptides and various synthetic recognition elements. Normally, Prof. Zourob discusses with the potential students who is interested to join the lab, their research interest, technical skills, future plans and try to design a research project which fits with both parties’ interest. Therefore, please contact him and discuss your interest. Nothing to lose.

Five recent publications

Prof. Ahmad Aljada

Focus of research

Motivated by an unyielding enthusiasm for unraveling the cellular processes that form the foundation of health and disease, my commitment lies in advancing the field of research pertaining to the mechanisms governing metabolic disorders and cancer. At the core of my investigations lies the phenomenon known as stress-induced premature senescence (SIPS), which plays a pivotal role in the emergence and progression of these debilitating ailments. My objective is to unveil the molecular basis of SIPS, identify novel biomarkers, and pave the way for therapeutic strategies. SIPS manifests through the emergence of senescence-associated traits, such as growth arrest and heightened expression of specific markers, in cells that have been exposed to stress. It is implicated in a multitude of diseases, including cancer, cardiovascular disease, and metabolic disorders. The mechanisms that underlie SIPS involve a complex interplay of factors, including telomere dysfunction, DNA damage, epigenetic alterations, and mitochondrial dysfunction. Cellular stressors have the capacity to inflict DNA damage, thereby prompting cells to initiate repair mechanisms and subsequently enter a state of growth arrest, ultimately leading to SIPS. Epigenetic modifications, such as DNA methylation, also contribute to the induction of SIPS. Furthermore, mitochondrial dysfunction, which impairs the cell's ability to generate energy, contributes to the onset of SIPS. Given the nature of SIPS and its association with a diverse range of diseases, further research is imperative in order to comprehensively comprehend its mechanisms and develop innovative therapeutic approaches to prevent and treat pathologies related to SIPS. My research employs cutting-edge methodologies, including metabolomics, proteomics, lipidomics, and transcriptomics, to delve into these areas.

Five recent publications

1. Zhra M, Al Saud A, Alzayer M, Okdah L, Tamim H, Fakhoury HM, et al. Cost effective in house COVID 19 reverse transcription polymerase chain reaction testing with yeast derived Taq polymerase. Ann Thorac Med 2024.
2. Mujammami, M.; Aleidi, S.M.; Buzatto, A.Z.; Alshahrani, A.; AlMalki, R.H.; Benabdelkamel, H.; Al Dubayee, M.; Li, L.; Aljada, A.; Abdel Rahman, A.M. Lipidomics Profiling of Metformin-Induced Changes in Obesity and Type 2 Diabetes Mellitus: Insights and Biomarker Potential. Pharmaceuticals (Basel) 2023, 16, doi:10.3390/ph16121717.
3. Galal M.A., Alouch S.S., Alsultan B.S., Dahman H., Alyabis N.A., Alammar S.A., Aljada A. Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance. Int. J. Mol. Sci. 2023, 24, 15006. https://doi.org/10.3390/ijms241915006.
4. Alshahrani A., Aljada A., Masood A., Mujammami A., Alfadda A.A., Musambil M., Alanazi I.O., Al Dubayee M., Abdel Rahman A.M., Benabdelkamel H.H. Proteomic Profiling Identifies Distinct Regulation of Proteins in Obese Diabetic Patients Treated with Metformin. Pharmaceuticals (Basel). 2023 Sep 2023;16(10):1345. doi: 10.3390/ph16101345.
5. Batha L, Aziz MA, Zhra M, Holail J, Al-Qahtani WS, Fakhoury R, Aljada A. Differential Gene Expression Signatures and Cellular Signaling Pathways induced by Lamin A/C Transcript Variants in MCF7 Cell Line. Front Biosci (Landmark Ed). 2023 Jun 12;28(6):113. doi: 10.31083/j.fbl2806113. PMID: 37395027.

Hanaa Fakhoury Hajeer, PhD

Focus of research

• Vitamin D metabolism and function
• Exploring the impact of different vitamin D forms and metabolites on various physiological processes. Investigating the mechanisms by which these variations influence health and disease.

Five recent publications

1. Fakhoury HMA, Arabi TZ, Tamim H, Chun RF, Grant WB, Hewison M, AlAnouti F, Pilz S, Annweiler C, Tzimagiorgis G, Haitoglou C, Karras SN. Associations of free, bioavailable and total 25-hydroxyvitamin D with neonatal birth anthropometry and calcium homoeostasis in mother-child pairs in a sunny Mediterranean region. Br J Nutr. 2023 Oct 26:1-8. doi: 10.1017/S000711452300243X. Epub ahead of print. PMID: 37880994.
2. Hamza FN, Daher S, Fakhoury HMA, Grant WB, Kvietys PR, Al-Kattan K. Immunomodulatory Properties of Vitamin D in the Intestinal and Respiratory Systems. Nutrients. 2023 Mar 30;15(7):1696. doi: 10.3390/nu15071696. PMID: 37049536; PMCID: PMC10097244.
3. Grant WB, Al Anouti F, Boucher BJ, Fakhoury HMA, Moukayed M, Pilz S, Al-Daghri NM. Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes. Biomedicines. 2023; 11(4):994. https://doi.org/10.3390/biomedicines11040994.
4. Karras, S.N.; Dursun, E.; Alaylıoğlu, M.; Gezen-Ak, D.; Annweiler, C.; Al Anouti, F.; Fakhoury, H.M.A.; Bais, A.; Kiortsis, D. Investigating the Role of Functional Polymorphism of Maternal and Neonatal Vitamin D Binding Protein in the Context of 25-Hydroxyvitamin D Cutoffs as Determinants of Maternal-Neonatal Vitamin D Status Profiles in a Sunny Mediterranean Region. Nutrients (2021), 13, 3082. https://doi.org/10.3390/nu13093082
5. Fakhoury, H. et al. Lung-Centric Inflammation of COVID-19: Potential Modulation by Vitamin D. Nutrients 13, 2216 (2021).

Ayodele Alaiya, MB.BS, MPH, PhD, FRCPath

Focus of research

Current Research Activities: My research interests encompasses experimental oncology and diagnostic pathology are directed at Translational Clinical Proteomics and biomarker discovery for clinical applications to different diseases in general. My mission of translational research towards Personalized Medicine mainly focus on molecular analysis of clinical samples from patients; including epithelial solid tumors, hematological malignancies, other non-malignant diseases, bodily fluids, stem cell subtypes as well as experimental cell types using Expression Proteomics approach. My life science research expertise is directed in mapping the molecular alterations involved in different disease conditions using state-of the-art proteomics technologies. Currently studying the complex protein expression patterns that may be decisive for the accurate diagnosis, biological behavior, treatment sensitivity and prognosis of specific human tumors. Others are biomarker discovery for kidney diseases and annotation of proteome maps for some selected human derived stem cells. I have well over 65 publications with in the field of Medical Proteomics in high impact factor peer reviewed journals. My research work have convincingly demonstrated Proof of concept studies that proteome analysis can be further developed into a “proteomedical scanner”, i.e., an artificial intelligence tool (protein fingerprint barcode) capable of assisting clinical decision makings in establishing a more accurate diagnosis and prognosis. With my proteomics research initiatives expertise, I have established international collaborations with academic institutions in Europe as well the Gulf region including King Faisal Specialist Hospital and Research Center Riyadh, Alfaisal University, Riyadh, KFMC, national Guard Hospital, University of Bahrain, Karolinska Institute and engaged in basic and translational clinical research and training and supervision of graduate students. I have years of experience of working with Institution review board including as member of Clinical Research Committee, Research ethics committee, and Basic Research Committee. I am keen to develop new innovative projects and collaborations with national and international research groups hopefully, generating new information and testing the real value of the technology in clinical practice.

Five recent publications

1. Alaiya A, Alharbi BM, Shinwari Z, Rashid M, Albinhassan TH, Bouchama A, Alwesmi MB, Mohammad S, Malik SS. Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models. International Journal of Molecular Sciences. 2024; 25(12):6787. https://doi.org/10.3390/ijms25126787.
2. Alkhayal Z, Shinwari Z, Gaafar A, Alaiya A. Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients. Int J Mol Sci. 2023 Sep 8;24(18):13841. doi: 10.3390/ijms241813841. PMID: 37762144; PMCID: PMC10531073
3. Al-Mutairy EA, Al Qattan S, Khalid M, Al-Enazi AA, Al-Saif MM, Imtiaz F, Ramzan K, Raveendran V, Alaiya A, Meyer BF, Atamas SP, Collison KS, Khabar KS, Hasday JD, Al-Mohanna F. Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells. Front Cell Dev Biol. 2023 Nov 30;11:1282868. doi: 10.3389/fcell.2023.1282868. PMID: 38099297; PMCID: PMC10720433.
4. Al-Dhfyan A, Alaiya A, Al-Mohanna F, Attwa MW, AlAsmari AF, Bakheet SA, Korashy HM. Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy. J Adv Res. 2023 Aug;50:177-192. doi: 10.1016/j.jare.2022.10.006. Epub 2022 Oct 26. PMID: 36307019; PMCID: PMC10403657.
5. Alaskar A, Abdulraqeb Ali A, Hassan S, Shinwari Z, Alaiya A, von Holzen U, Miller L, Kulik G. Inhibition of signaling downstream of beta-2 adrenoceptor by propranolol in prostate cancer cells. Prostate. 2023 Feb;83(3):237-245. doi: 10.1002/pros.24455. Epub 2022 Nov 14. PMID: 36373761; PMCID

Serdar Coskun, DVM, PhD

Focus of research

My interest is mainly in reproductive physiology and infertility. At the beginning of my carrier, I involved in intensive research in vitro oocyte maturation and effect of growth factors on the process in animals and human gametes. Currently, most of my research is in genetics of infertility and preimplanatation genetic testing. Moreover, morphokinetics of early embryo development and its relation to embryo development and treatment success by using artificial intelligence model are in my current research projects.

Five recent publications

1. Kashir J, Mistry BV, Rajab MA, BuSaleh L, Abu-Dawud R, Ahmed HA, Alharbi S, Nomikos M, AlHassan S, Coskun S, Assiri AM. The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and mice. Hum Reprod. 2024 Apr 26: deae 078. doi: 10.1093/humrep/deae078. Epub ahead of print. PMID: 38670547.
2. AlAbdi L, Maddirevula S, Shamseldin HE, Khouj E, Helaby R, Hamid H, Almulhim A, Hashem MO, Abdulwahab F, Abouyousef O, Alqahtani M, Altuwaijri N, Jaafar A, Alshidi T, Alzahrani F; Mendeliome Group; Alkuraya FS. Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families. Nat Commun. 2023 Aug 29;14(1):5269. doi: 10.1038/s41467-023-40909-3
3. Kashir J, Mistry BV, BuSaleh L, Nomikos M, Almuqayyil S, Abu-Dawud R, AlYacoub N, Hamdan H, AlHassan S, Lai FA, Assiri AM, Coskun S. Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm. Pharmaceuticals. 2023; 16(2):198. https://doi.org/10.3390/ph16020198
4. Daghestani MH, Alqahtani HA, AlBakheet A, Al Deery M, Awartani KA, Daghestani MH, Kaya N, Warsy A, Coskun S, Colak D. Global Transcriptional Profiling of Granulosa Cells from Polycystic Ovary Syndrome Patients: Comparative Analyses of Patients with or without History of Ovarian Hyperstimulation Syndrome Reveals Distinct Biomarkers and Pathways. Journal of Clinical Medicine. 2022; 11(23):6941. https://doi.org/10.3390/jcm11236941
5. Coskun S, Maddirevula S, Awartani K, Aldeery M, Qubbaj W, Kashir J, Alkuraya FS. Recurrent spontaneous oocyte activation causes female infertility. J Assist Reprod Genet. 2022 Feb 14. doi: 10.1007/s10815-022-02435-x. Epub ahead of print. PMID: 35156150.

Garwin Kim Sing, PhD, Postgrad. Dip. Ed.

Focus of research

My past research activity has been focused mainly on viral immunopathology with respect to cytokines, T cell and macrophage activity, electron microscopy and bioinformatics. In recent years, I have been involved more with looking at the antibacterial effects of nanoparticles and the cytotoxic effects of various natural compounds.

Five recent publications

1. Alsharaeh, E.H., Alazzam, S., Ahmed, F., Arshi, N., Al-Hindawi, M., Kim Sing, G. Green synthesis of silver nanoparticles and their graphene oxide nanocomposites as antibacterial agents: A bio-inspired approach. Acta Metall. Sin. DOI 10.1007/s40195-016-0485-z. 2016.
2. Mubarak, A., Kim Sing, G., Senok, A. First report of blaCTX-M-28 in Enterobacteriaceae isolates in the United Arab Emirates. J. Pathogens DOI:10.1155/2018/1304793. 2018
3. Senok A., Somily AM, Nassar R, Garaween, G., Kim Sing G., Müller E, Reissig A, Gawlik D, Ehricht R, Monecke S. Infect Drug Resist. 2019 Sep 3;12:2739-2746. doi: 10.2147/IDR.S218870. eCollection 2019.PMID: 31564924
4. Shafqat, A., Khan, J.A., Alkachem, A.Y., Sabur, H., Alkattan, K., Yaqinuddin, A., Kim Sing, G. How neutrophils shape the immune response: Reassessing their multifaceted role in health and disease. Int. J. Mol. Sci. 2023 24:17583-17592.
5. Kim Sing, G., Rohra, D., Kulik, G and Aljada, A.S. What has genomics done for us? A review of the advancements in the biomedical sciences resulting from the deciphering of the human genome. J. Sci. and Tech. Res., 2024. 54:45961-45970.

Dr. Ovidiu Constantin Baltatu, MD PhD

Focus of research

Dr. Baltatu's research focuses on translational medicine and biomarker discovery, particularly in the areas of:

• Cardiovascular and metabolic diseases
• Early disease detection and prevention strategies
• Biomarker identification and validation for conditions like diabetes, hypertension, and cardiovascular disease
• Applications of data science and machine learning in biomedical research
• Digital health technologies and their integration into clinical practice

Five recent publications

1. Evidence for the druggability of aldosterone targets in heart failure: A bioinformatics and data science-driven decision-making approach. Salgado Rezende de Mendonça L, Senar S, Moreira LL, Silva Júnior JA, Nader M, Campos LA, Baltatu OC. Comput Biol Med. 2024 Mar;171:108124.
2. Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders. Campos LA, Baltatu OC, Senar S, Ghimouz R, Alefishat E, Cipolla-Neto J. Int J Mol Sci. 2023 Jan 3;24(1):860.
3. Burnout and Cardiovascular Risk in Healthcare Professionals During the COVID-19 Pandemic. Alameri F, Aldaheri N, Almesmari S, et al. Front Psychiatry. 2022 Apr 4;13:867233.
4. Urinary Angiotensinogen-Melatonin Ratio in Gestational Diabetes and Preeclampsia. Valias GR, Gomes PRL, Amaral FG, et al. Front Mol Biosci. 2022 Mar 2;9:800638.
5. Heart Rate Variability Indices as Possible Biomarkers for the Severity of Post-traumatic Stress Disorder Following Pregnancy Loss. de Faria Cardoso C, Ohe NT, Bader Y, et al. Front Psychiatry. 2022 Jan 4;12:700920.